Matt McIlwain

Matt McIlwain

Investor at Exa
Sea Island, Georgia, United States

Matt McIlwain currently serves as a board member at several companies, including A-Alpha Bio, Amperity, Axiom Math, Booster, and EdgeRunner AI. He has previously held board roles at Accolade, Inc. (which went public in 2021), Apptio (which went public in 2016), Farecast, and Isilon Systems (which went public in 2006), as well as serving as Vice President of Business Process at Genuine Parts Company.

Shift AI Podcast: Seattle's place at the center of the AI universe, with Madrona's Matt McIlwain

On this week’s GeekWire Podcast, we're featuring an episode of Shift AI, a podcast hosted by Boaz Ashkenazy, CEO of AI solutions provider Simply Augmented, with guest Matt McIlwain of Seattle-based venture capital firm Madrona Venture Group. A thriving tech hub requires access to ideas, people, and experiments that produce collective lessons sooner and with greater fidelity than anywhere else. This is what made the Seattle area the cloud capital of the world. It also positions the region as one of the world’s top centers of excellence for artificial intelligence. That’s one of the insights from Matt McIlwain, managing director…

IBM Acquires Apptio for $4.6B After 16-Year Journey Including 2016 IPO and $1.94B Vista Buyout

Apptio's 16-year journey from a challenging IPO in 2016 to a $4.6 billion acquisition by IBM in 2023 exemplifies perseverance and long-term vision in enterprise tech. Originally valued at over $500 million at IPO, the company rebounded after setbacks, was acquired by Vista Equity Partners for $1.94 billion, and then sold to IBM, highlighting its growing impact in tech spending management.

Madrona’s Matt McIlwain: In-person interaction vital as firm raises $690M and opens Palo Alto office

Madrona Venture Group managing director Matt McIlwain says hybrid work hasn’t been solved and emphasizes that in-person interaction is essential for trust-based VC–founder relationships, prompting regular partner office days and a new Palo Alto office. Madrona recently closed a record $690 million across two funds, driven in part by prior wins like its 2020 Snowflake investment.

Amperity cuts 13 roles (3% of staff) amid reorganization while planning continued hires and investments

Seattle customer-intelligence startup Amperity laid off 13 employees (about 3% of its 375-person workforce), primarily from its talent acquisition team, while saying it will continue hiring and invest in growth. CEO Barry Padgett attributed the cuts to organizational alignment with strategic growth plans; the company became a unicorn in July 2021 after a $100 million raise and values at $1 billion.

Matt McIlwain, Madrona Venture Group Managing Director, veteran investor in seed and Series A tech companies

Matt McIlwain is a Managing Director at Madrona Venture Group in Seattle with over 25 years investing in seed and Series A technology companies; Madrona manages over $2B and was an early investor in Amazon, Smartsheet, Isilon, Redfin, and Snowflake. He focuses on cloud computing, data-driven and intelligent applications, champions the 'Learning Loop' for entrepreneurs, and previously worked at Genuine Parts Company, McKinsey & Company, and Credit Suisse.

Madrona’s Matt McIlwain Interviews Starburst CEO Justin Borgman on Founding Starburst, Cloud Marketplaces, and Presto Renaming to Trino

Madrona’s Matt McIlwain interviews Starburst Data CEO and co-founder Justin Borgman about founding Starburst, lessons from his first startup Hadapt, the importance of cloud partnerships and marketplaces for startups, the renaming of Starburst’s query engine from Presto to Trino, and guidance on building future-proof architectures.

Qumulo CEO Bill Richter Discusses Microsoft Azure Partnership and Enterprise Collaboration on Madrona’s Founded and Funded

Madrona partners Matt McIlwain and Aseem Datar interview Qumulo CEO Bill Richter about building meaningful enterprise partnerships, including Qumulo’s recent launch of Qumulo on Azure as a Service with Microsoft. The episode explores why startups partner with large enterprises, how those partnerships create mutual value, and practical advice for making them work.

Andreessen Horowitz, Madrona and other tech VCs ramp up bets on AI-driven biotech startups as founders from software enter life sciences

Tech venture capital firms like Andreessen Horowitz and Seattle’s Madrona Venture Group are increasingly investing in life-science startups that use AI, machine learning and data science to speed drug discovery and development. Investors are following founders who transitioned from software to biotech—such as Sujal Patel of Nautilus and Terry Myerson of Truveta—seeing reduced perceived risk and new opportunity at this intersection.

Amperity CEO and co-founder Kabir Shahani steps down; Barry Padgett named CEO as company scales after $100M round

Amperity CEO and co-founder Kabir Shahani has relinquished the CEO title seven months after the company raised $100 million and reached unicorn status; president and COO Barry Padgett becomes CEO and Monica Pool Knox is named chief people officer. The company called 2021 a record year, offered no explanation for Shahani's departure, and said it will focus on scaling its customer-data software business.

Vulcan Capital renamed Cercano Management and spun off as independent firm managing Allen-era assets

Vulcan Capital, the investment arm created to manage late Microsoft co-founder Paul Allen’s holdings, has been spun off and renamed Cercano Management, a privately held firm working with multiple investors and family foundations. Cercano, based in Bellevue, will remain connected to Allen’s estate, continues Vulcan’s low-profile approach, and was recently disclosed as an investor in a $5.9 million round for Seattle startup Pendulum.

Pack Ventures launches Seattle syndicate to back UW-linked startups, pledges 10% of future profits to University of Washington

Pack Ventures, a new early-stage Seattle VC, will invest $100K–$200K checks in startups tied to the University of Washington and has already backed five companies including Jeeva Wireless, Talus.bio and Monod Bio; the firm will return 10% of individual future profits to UW. The syndicate includes more than 35 founding investors from the Seattle VC and entrepreneur community and will target AI, robotics, computational biology, enterprise software and other high-growth areas.

Madrona and Goldman Sachs Publish Inaugural IA40 of Top 40 Private AI Business-App Startups; Four Seattle Firms Included

Madrona Venture Group and Goldman Sachs released the inaugural Intelligent Applications Top 40 (IA40) list of private companies building business AI applications, based on votes from 40 venture firms plus Amazon and Microsoft and narrowed by 50 judges from over 220 nominees. Four Seattle-area companies — Amperity, OctoML, SeekOut, and one unnamed here — made the list; Amperity recently raised $100 million to reach unicorn status and OctoML raised $85 million.

A-Alpha Bio raises $20M Series A led by Madrona to expand Seattle lab and scale protein-discovery platform

University of Washington spinout A-Alpha Bio raised $20 million in Series A funding led by Madrona Venture Group to expand downtown Seattle lab space and grow its machine-learning team for its protein-discovery platform. The company combines computational tools and yeast-based experiments to generate large protein-interaction datasets used to predict therapeutic protein candidates for diseases including COVID-19.

Organizations

See all 36
  • Thira logo
    Thira Director 2026–present · current
  • Exa Investor 2026–present · current
  • Thira Board Member 2026–present · current

Education

  • Harvard Business School Master of Business Administration (MBA) · 1990–1992
  • Dartmouth College Bachelor's degree, Government with economics · 1983–1987

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